How It
Works
the WINLEVI® Way

Models shown are not actual patients.
Mechanism of WINLEVI in acne vulgaris is unknown.1

What's been missing in the topical treatment of acne vulgaris

A topical medication focused on inhibiting the effects of androgens on the cells in sebaceous glands had been missing. Androgens are the most important of all hormones regulating sebum production.1-3

Available topical options did not address all 4 elements of acne pathophysiology.1-3
Certain oral hormonal therapies are recommended for some female patients with acne, but use in males is limited due to potential systemic side effects.4,5

WINLEVI® (clascoterone cream 1%) Targeting Hyper-keratinization, Inflammation and C. acnes bacteria
A different way to treat acne    •
First in class

Topical mechanism to inhibit androgen receptors in acne1,8

Targets androgen component of acne in female AND male patients1,4,9

WINLEVI (clascoterone) cream 1% inhibits the effects of androgen hormones on cells in sebaceous glands to help reduce sebum production and inflammation.1,9

The exact mechanism of WINLEVI in acne vulgaris is unknown.1

Typical Acne Formation

DHT Androgens in Acne Development

Androgens such as testosterone and dihydrotestosterone (DHT) play a key role in acne development in both sexes.5,10

WINLEVI® (clascoterone cream 1%) MOA

Within the skin, androgens bind to androgen receptors, causing increased sebum production and inflammation.9

winlevi mechanism of action

WINLEVI binds to the androgen receptor, competing with the binding of androgens such as DHT.1,4,9

Studies suggest this inhibits the action of androgen receptors on cells in the sebaceous gland, reducing sebum production and inflammation.1,4,9

However, the exact mechanism of WINLEVI in acne vulgaris is unknown.1

WINLEVI® (clascoterone cream 1%) Targeting Hyper-keratinization, Inflammation and C. acnes bacteria
Efficacy the WINLEVI Way

Models shown are not actual patients.

WINLEVI provides you with another option in your treatment approach

See the results